bola class II nuc seqs

BoLA Nomenclature

International Society for Animal Genetics

BoLA class II nucleotide sequences, 1996.
Report of the ISAG BoLA Nomenclature Committee.

Authors:
CJ Davies, L Andersson, SA Ellis, EJ Hensen, HA Lewin, S Mikko, NE Muggli-Cockett, JJ van der Poel and GC Russell

For authors' addresses and contact details see the BoLA nomenclature committee page.

Correspondence: Dr. G.C. Russell
Telephone: (44) 131-527 4354; Fax: (44) 131-440-0434
E-mail: george.russell@bbsrc.ac.uk

The BoLA class II nucleotide sequences included here are taken from the sources listed in the accompanying paper (Davies et al. 1997). The alignments include only the protein coding sequences, and were compiled from sequence data extracted from database entries or published papers. When anomalies were detected, the original authors were contacted to provide clarification or correction. The authors welcome any information which would help to maintain the accuracy of the alignments, and identify any errors.

In each sequence alignment table, the prototype sequence chosen was the closest to full-length available with the highest similarity to the majority of alleles. The layout of the alignments follows the system used for alignment of the HLA class II nucleotide sequences ( Marsh and Bodmer, 1995): identity with the prototype sequence is indicated by hyphens (-), gaps inserted to maintain alignment are marked by dots (.), and regions where sequence data were not available are indicated by asterisks (*). Complete lines which contained no sequence data were removed from the alignments to save space. The alignments are presented in codon triplets, numbered from the first codon of the mature peptide (or from the first codon sequenced). Gaps are included to show the positions of exon boundaries in genomic sequences, or the domain boundaries where only cDNA sequences were available.

Alignments: DRA | DRB | DQA | DQB | DYA | DIB | DMA | DMB

References

Davies C.J., Andersson L., Ellis S.A., Hensen E.J., Lewin H.A., Mikko S., Muggli-Cockett N.E., van der Poel J.J. & Russell G.C. (1997)
Nomenclature for factors of the BoLA system, 1996. Report of the ISAG BoLA Nomenclature Committee.
Animal Genetics, (In press).
Marsh S.G.E & Bodmer J.G. (1995)
HLA Class II region nucleotide sequences, 1995.
Tissue Antigens 45, 258-280.

DRA sequence

Exon 1 1 Exon 2 DRA*0101 ATG GCC ATA ACC AGG GTC CCA ATA TTA GGA CTT TTC ATC ACT GTC CTG ATC GGC CTA CAG GAA TCG TGG GCT ATT AAA G AG AAT CAT GTG ATC ATC CAA 10 20 30 40 DRA*0101 GCT GAG TTC TAT CTG AAA CCT GAG GAA TCA GCC GAG TTT ATG TTT GAC TTT GAT GGT GAT GAG ATT TTC CAC GTG GAT ATG GGG AAG AAG GAG ACG GTG TGG 50 60 70 DRA*0101 CGG CTT CCA GAA TTT GGA CAT TTT GCC AGC TTT GAG GCT CAG GGT GCC CTG GCC AAT ATG GCT GTG ATG AAA GCC AAC CTG GAC ATC ATG ATA AAG CGC TCC 80 Exon 3 90 100 110 DRA*0101 AAC AAC ACC CCA AAC ACC AAT G TT CCT CCA GAA GTG ACT CTG CTC CCA AAC AAG CCT GTG GAA CTG GGA GAG CCC AAC ACA CTC ATC TGC TTC ATT GAC 120 130 140 DRA*0101 AAG TTC TCC CCA CCC GTG ATC AGT GTC ACA TGG CTT CGA AAT GGC AAA CCT GTC ACT GAT GGA GTG TCA CAG ACG GTC TTC CTG CCC AGG AAT GAC CAC CTT 150 160 170 DRA*0101 TTC CGC AAG TTC CAC TAC CTC CCC TTC CTG CCC ACA ACA GAG GAT GTC TAT GAC TGC AAG GTG GAG CAC TTG GGT TTG AAT GAG CCT CTT CTC AAG CAC TGG Exon 4 190 200 210 DRA*0101 TAT G AG GAA GCT CCA GCC CCC CTC CCA GAG ACC ACA GAG AAT GCA GTG TGT GCC CTG GGC CTG ATT GTG GCT CTG GTG GGC ATC ATT GCA GGG ACC ATC 220 230 DRA*0101 TTC ATC ATC AAG GGC GTG CGC AAA GCC AAC ACC GTT GAA CGC CGA GGG CCT CTG TGA

DRB sequences

Exon 1 1 DRB3*0102 ATG GTG TGC CTG TAT TTC TCT GGA GGC TCC TGG ATG GCA GCT CTG ATA GTG ATG CTG ATG GTG CTG TGC CCT CCC CTG GCC TGG GCC AGG GAG ATC CAA CCA DRB3*1601 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*2101 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*2201 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*2801 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*3101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*3201 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** ****** *** *** *-- DRB1*0101 --- --- --A --- -.. --- C-C A-- --- --- --- --- --- --- --- -C- --- --A --- --- --- A-- AA- --- --- --- --T --- --- --- --C -C- --C$A-- DRB1*0201 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *-- DRB2*0101 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *-G Exon 2 10 20 30 DRB3*0102 CAT TTC CTG GAG TAT TCT AAG AGC GAG TGT CAT TTC TTC AAC GGG ACC GAG CGG GTG CGG TTC CTG GAC AGA TAC TAC ACT AAT GGA GAA GAG ACC GTG CGC DRB3*0101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*0201 *** *** **- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- CA- --- --- --- --- TT- --- --- DRB3*0301 *** *** **- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- -C- -T- TA- --- --- --- --- TT- --- --- DRB3*0302 *** *** **- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- -C- -T- TA- --- --- --- --- TT- --- --- DRB3*0401 *** *** **- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*0501 *** *** **- --- --- CA- --- --T --- --- --- --- --- --- --- --- --- --T T-- --- -A- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*0502 *** *** **- --- --- CA- --- --- --- --- --- --- --- --- --- --- --- --T T-- --- -A- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*0503 *** *** **- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --T T-- --- -A- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*0601 *** *** **- --- --- -G- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- -G- -T- CA- --- --- --- --- TT- --- --- DRB3*0701 *** *** **- --- --- -G- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- -T- CA- --- --- --- --- TT- --- --- DRB3*0801 *** *** **- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- CA- --- --- --- --- CT- --- --- DRB3*0901 *** *** **- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- -C- -T- TA- --- --- --- --- -A- --- --- DRB3*0902 *** *** **- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- -C- -T- TA- --- --- --- --- -A- --- --- DRB3*1001 *** *** **- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- CA- --- --- --- --- TA- --- --- DRB3*1002 *** *** **- --- --- -A- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- CA- --- --- --- --- TA- --- --- DRB3*1101 *** *** **- C-- --- CA- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- C-- -T- TA- --- --- --- --- TA- --- --- DRB3*1201 *** *** **- --- --- A-C --- -AA --- --- --- --- --- --- --- --- --- --- --- --- --- --- A-- --- --- -T- CA- --- --- --- --- TT- --- --- DRB3*1202 *** *** **- --- --- A-C --- -AA --- --- --- --- --- --- --- --- --- --- --- --- --- --- A-- --- --- -T- CA- --- --- --- --- TT- --- --- DRB3*1301 *** *** **- --- --- CT- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*14011 *** *** **- C-- --- CA- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- C-- -T- TA- --- --- --- --- TT- --- --- DRB3*14012 *** *** *** C-- --- CA- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- C-- -T- TA- --- --- --- --- TT- --- --- DRB3*1501 *** *** **- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -T- CA- --- --- --- --- TT- --- --- DRB3*1502 *** *** **- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -T- CA- --- --- --- --- TT- --- --- DRB3*1601 --- --- --- --- --- A-C --- -AA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- CA- --- --- --- --- TT- --- --- DRB3*1701 *** *** **- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- -T- TA- --- --- --- --- TA- -C- --- DRB3*1702 *** *** **- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- -T- TA- --- --- --- --- TA- -C- --- DRB3*1703 *** *** *** --- --- --- -C- G-- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -T- TA- --- --- --- --- TA- -C- --- DRB3*1801 *** *** **- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- -T- CA- --- --- --- --- TT- --- --- DRB3*1802 *** *** **- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- CA- --- --T --- --- TT- --- --- DRB3*1901 *** *** **- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*20011 *** *** **- --- --- -G- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- --- -T- TA- --- --- --- --- CG- --- --- DRB3*20012 *** *** **- --- --- -G- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- --- -T- TA- --- --- --- --- CG- --- --- DRB3*2002 *** *** **- --- --- -G- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- --- -T- TA- --- --- --- --- CG- --- --- DRB3*2003 *** *** *** --- --- -G- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- --- -T- TA- --- --- --- --- CG- --- --- DRB3*2101 --- --- --- --- --- --- -C- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*2201 --- --- --- C-- --- CA- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- C-- -T- TA- --- --- --- --- TA- --- --- DRB3*2202 *** *** **- C-- --- CA- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- C-- -T- --- --- --- --- --- TA- --- --- DRB3*2301 *** *** **- --- --- A-C --- -AA --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*2401 *** *** **- --- --- -G- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*25011 *** *** **- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -T- CA- --- --- --- --- TT- --- --- DRB3*25012 *** *** **- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -T- CA- --- --- --- --- TT- --- --- DRB3*2601 *** *** **- --- --- A-C --- -AA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- CA- --- --- --- --- --- --- --- DRB3*2701 *** *** **- --- --- -A- --- --A --- --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- -G- --- --- --- --- --- --- --- --- --- DRB3*2702 *** *** **- --- --- -A- --- --A --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -G- --- --- --- --- --- --- --- --- --- DRB3*2703 *** *** **- --- --- -A- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- --- --- --- --- --- --- --- --- --- DRB3*2704 *** *** **- --- --- -A- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- -T- CA- --- --- --- --- TT- --- --- DRB3*2705 *** *** **- --- --- -A- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- --- --- --- --- --- --- --- --- --- DRB3*2706 *** *** *** --- --- -A- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- --- --- --- --- --- --- --- --- --- DRB3*2801 --- --- --- C-- --- CA- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- C-- -T- TA- --- --- --- --- TT- --- --- DRB3*2802 *** *** *** C-- --- CA- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- C-- -T- TA- --- --- --- --- TA- --- --- DRB3*2901 *** *** **- --- --- G-- C-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- -T- CA- --- --- --- --- TT- --- --- DRB3*3001 *** *** **- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*3002 *** *** **- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- --- --- --- --- --- --- --- --- DRB3*3101 --- --- --- --- --- -A- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -T- TA- --- --- --- --- TT- --- --- DRB3*3201 --- --- --- --- --- -G- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*3202 *** *** **- --- --- -G- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*3301 *** *** **- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*3401 *** *** **- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- -C- -T- TA- --- --- --- --- TT- --- --- DRB3*3402 *** *** *** --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- -C- -T- TA- --- --- --- --- TT- --- --- DRB3*3501 *** *** **- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- -A- --- --- DRB3*3601 *** *** **- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*3701 *** *** *** --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*3801 *** *** *** --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*3901 *** *** *** --- --- --- -C- G-- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -T- TA- --- --- --- --- TA- --- --- DRB3*4001 *** *** *** --- --- --- -C- G-- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- -T- TA- --- --- --- --- TA- -C- --- DRB1*0101 --- --G A-- -T- C-G GGC --- TC- --- --- --- --- -C- -T- C-- --T --- -A- --A --A --- T-- -C- --- --- -T- TA- --C CAG A-G --- TTG --- -AT DRB1*0201 --- --G A-- -T- C-G GGC --- TC- --- --- --- --- -C- -T- C-- --T --- -A- --A --- --- T-- -C- --- --- -T- TA- --C CAG A-G --- TTG --- -AT DRB2*0101 --- --- A-C C-T C-G -T- --- G-T --- --- -G- --- -C- --- --- TTG --- --- A-- --- --- T-T -C- --- --- AT- TAC --C ACG C-G --- GAT --- -AT 40 50 60 70 DRB3*0102 TTC GAC AGC GAC TGG GGC GAG TTC CGG GCG GTG ACC GAG CTG GGG TGG CAG GAC GCC GAG TAC TGG AAC AGC CAG AAG GAC TTC CTG GAG GAG AAG CGG GCC DRB3*0101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*0201 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -C- --- --- --- --- --- --- --- --- ... --G A-- --- --- CG- GC- --- --- DRB3*0301 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -C- --- --- A-- --- --- --- --- --- --- --- --G --- --- C-- --- --- --- DRB3*0302 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -C- --- --- A-- --- --- --- --- --- --- --- --G --- --- C-- --- --- --- DRB3*0401 --- --- --- --- --- --- --- --- -A- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --- A-- --- --- CG- G-- --- --- DRB3*0501 --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --G A-- --- --- CG- --- --- --- DRB3*0502 --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --- --G --- --- CG- --- --- --- DRB3*0503 --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --G A-- --- --- CG- --- --- --- DRB3*0601 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -G- -T- --- --- C-- -T- --- --- --- --- --G A-- --- --- CG- --- --- --- DRB3*0701 --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- C-- -GC -T- --- --- C-G --- --- --- --- --- --- --- --- --- --- -G- --- --- DRB3*0801 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- TC- --- -T- C-- -T- --- --- --- --- --- --- --- --- --C G-- --- --T DRB3*0901 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -C- --- --- --- --- --- --- --- --- --- --G A-- --- --- CG- --- --- --- DRB3*0902 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -C- --- --- --- --- --- --- --- --- --- --G A-- --- --- --- -G- --- --- DRB3*1001 --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- CA- -G- -T- --- --- --- --C --- --- --- --- --- --- --- --- CG- GC- --- --- DRB3*1002 --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- CA- -G- -T- --- --- --- --C --- --- --- --- --- --- --- --- CG- GC- --- --- DRB3*1101 --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- C-- -C- TC- --- --- --- --- --- --- --- --- --- --- --- --- CG- -G- --- --- DRB3*1201 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -C- --- --- --- --- --- --- --- --- --- --G A-- --- --- CG- GC- --- --- DRB3*1202 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -C- --- --- --- --- --- --- --- --- --- --G A-- --- --- CG- GG- --- --- DRB3*1301 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -C- --- --- A-- --- --- --- --- --- --- --- --G --- --- CG- --- --- --- DRB3*14011 --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- C-- -C- -C- --- --- C-G --- --- --- --- --- --- --- --- --- C-- --- --- --- DRB3*14012 --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- C-- -C- -C- --- --- C-G --- --- --- --- --- --- --- --T --- C-- --- --- --- DRB3*1501 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -G- -T- --- --- C-G -T- --- G-- --- --- --- AC- --- --- CG- G-- --- --- DRB3*1502 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -G- TC- --- --- C-G -T- --- G-- --- --- --- AC- --- --- CG- G-- --- --- DRB3*1601 --- --T --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -C- --- --- A-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*1701 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --G A-- --- --- CG- G-- --- --- DRB3*1702 --- --- --- --- --- --- --- --- T-- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --G A-- --- --- CG- G-- --- --- DRB3*1703 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --G A-- --- --- CG- G-- --- --- DRB3*1801 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- -C- --- --- C-G --- --- --- --- --- --- AC- --- --- CG- G-- --- --- DRB3*1802 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- -C- --- --- C-G --- --- --- --- --- --- AC- --- --- CG- G-- --- --- DRB3*1901 --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- C-- -C- TC- --- --- --- --- --- --- --- --- --- A-- --- --- CG- --- --- --- DRB3*20011 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- TC- --- --- --- --- --- --- --- --- --- --- --- --- C-- -G- --- --- DRB3*20012 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- TC- --- --- --- --- --- --- --- --- --- --- --- --- C-- -G- --- --- DRB3*2002 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -G- --- --- DRB3*2003 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -G- --- --- DRB3*2101 --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- C-- --- --- --- --- C-G --- --- --- --- --- --- --- --- --- --- -G- --- --- DRB3*2201 --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- C-- -C- TC- --- --- C-- --- --- --- --- --- --G A-- --- --- CG- -G- --- --- DRB3*2202 --- --- --- --- --- --- --- -A- --- --- T-- --- --- --- --- C-- -C- TC- --- --- C-- --- --- --- --- --- --G A-- --- --- CG- -G- --- --- DRB3*2301 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- C-G --- --- --- --- --- --- AC- --- --- --C G-- --- --- DRB3*2401 --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- C-- -C- --- --- --- --- --- --- --- --- --- --G A-- --- --- --- -G- --- --- DRB3*25011 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- -C- --- --- C-G --- --- --- --- --- --- AC- --- --- --C G-- --- --T DRB3*25012 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- -C- --- --- C-G --- --- --- --- --- --- AC- --- --- --C G-- --- --- DRB3*2601 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -GC -T- --- --- C-G --- --- --- --- --- --- AC- --- --- CG- GC- --- --- DRB3*2701 --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- C-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- --- --- DRB3*2702 --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- C-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- --- --- DRB3*2703 --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- C-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- --- --- DRB3*2704 --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- C-- -C- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- --- --- DRB3*2705 --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- C-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- --- --- DRB3*2706 --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- C-- -C- TC- --- --- --- --- --- --- --- --- --- A-- --- --- --- -G- --- --- DRB3*2801 --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- C-- -C- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- --- --- DRB3*2802 --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- C-- -C- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- --- --- DRB3*2901 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- CA- -G- -T- --- --- C-G --- --- --- --- --- --- ACG --- --- CG- G-- --- --- DRB3*3001 --- --- --- --- --- --- --- --- --- --- T-- --- --- --- --- C-- --- --- --- --- C-G --- --- --- --- --- --G A-- --- --- --C G-- --- --- DRB3*3002 --- --- --- --- --- --- --- --- --- --- T-- --- --- --- --- C-- --- --- --- --- C-G --- --- --- --- --- --G A-- --- --- --C G-- --- --- DRB3*3101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- -C- --- --- C-- --- --- --- --- --- --- --- --- --- C-- --- --- --- DRB3*3201 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --G A-- --- --- CG- G-- --- --- DRB3*3202 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --G A-- --- --- CG- G-- --- --- DRB3*3301 --- --- --- --- --- --- --- -A- -A- --- --- --- --- --- --- C-- -C- TC- --- --- C-- --- --- --- --- ... --G A-- --- --- C-- -G- --- --- DRB3*3401 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -G- -T- --- --- C-G -T- --- --- --- --- --- --G --- --- C-- --- --- --- DRB3*3402 --- --- --- --- --- --- --- -A- --- --- --- --- --- --A --- C-- -G- -T- --G A-- C-G -T- --- --- --- --- --- --G --- --- C-- --- --- --- DRB3*3501 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- CG- --- --- --- DRB3*3601 --- --- --- --- --- --- --- --- --- --- T-- --- --- --- --- C-- --- --- --- --- C-G --- --- --- --- --- --- AC- --- --- CG- G-- --- --- DRB3*3701 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --- AC- --- --- --C G-- --- --T DRB3*3801 --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- C-- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- CG- --- --- --- DRB3*3901 --- --- --- --- --- --- --- --- -A- --- --- --- --- --- --- C-- -C- --- --- --- --- --- --- --- --- --- --- AC- --- --- CG- G-- --- --- DRB3*4001 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -C- --- --- A-- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- DRB1*0101 --T -T- --- A--#GT- --T --- --- A-- --A --- --- --- -G- --C A-- -TC TT- --T --- AGT --- --T CAT --- --- --- --A G-- --- TGA -C- -A- --T DRB1*0201 --T -T- --- ---#GT- --T --- -C- A-- --A --- --T --- -G- --C A-- -TC TT- --T --- AGT --- --T CAT --- --- --- --T G-- A-- TGA -C- -A- --T DRB2*0101 --- --- --- --T GT- --G --- --- AC- --C C-- --G --- --- --- A-- -T- --- --- --- --- --- --- CAG --A --- --- --- A-- --- C-- -T- --- --- 80 90 Exon 3 100 DRB3*0102 GAG GTG GAC AGG GTG TGC AGA CAC AAC TAC GGG GGT ATG GAG AGT TTC ACT GTG CAG CGG CGA G TG GAG CCT ACA GTG ACT GTG TAT CCT GCA AAG ACT DRB3*0101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- --- --- --- --- --- DRB3*0201 -C- --- --- -C- TAC --- --- --- --- --- --- --C G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0301 A-T --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- --- --- --- - ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0302 A-T --- --- -C- TAC --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0401 -C- --- --- -C- TAC --- --- --- --- --- --- --C G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0501 A-T --- --- -C- TAC --- --- --- --- --- --- -TC G-T --- --- --- --- --- --- --- --- - ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0502 A-T --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0503 A-T --- --- -C- TAC --- --- --- --- --- --- -TC T-T --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0601 --- --- --- -C- --- --- --- --- --- --- --- -T- GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0701 --- --- --- --- --- --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0801 TC- --- --- -C- TAC --- --- --- --- --- --- -TC G-T --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0901 A-T --- --- --- --- --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*0902 --- --- --- --- --- --- --- --- --- --- --- -TC GGT --- --- --- --- --- --- --- --- - ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1001 -C- --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1002 -C- --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1101 --- --- --- -C- --- --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1201 -C- --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- --- --- --- - ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1202 -C- --- --- -C- TAC --- --- --- --- --- --- -TC GGT --* *** *** *** *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1301 A-T --- --- -C- TAC --- --- --- --- --- --- -TC G-- --- --- --- --- --- --- T-- --- - ** *** *** *** *** *** *** *** *** *** *** *** DRB3*14011 --- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- --- --- - ** *** *** *** *** *** *** *** *** *** *** *** DRB3*14012 --- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1501 T-T --- --- -C- TAC --- --- --- --- --- --- -TC G-T --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1502 T-T --- --- -C- TAC --- --- --- --- --- --- -TC G-T --* *** *** *** *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1601 -C- --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1701 T-T --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1702 T-T --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1703 T-T --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1801 T-T --- --- -C- TAC --- --- --- --- --- --- --C G-- --- --- --- --- --- --- --- --- - ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1802 T-T --- --- -C- TAC --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*1901 A-T --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*20011 -C- --- --- -C- TAC --- --- --- --- --- --- -TC G-T --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*20012 -C- --- --- -C- TAC --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2002 -C- --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2003 -C- --- --- -C- TAC --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2101 --- --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- --- --- --- - -- --A --- -T- --- --- --- *** *** *** *** *** DRB3*2201 --- --- --- --- --- --- --- --- --- --- --- -TC GGT --- --- --- --- --- --- --- --- - -- --A --- -T- --- --- --- *** *** *** *** *** DRB3*2202 --- --- --- --- --- --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2301 -CT --- --- -C- TAC --- --- T-- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2401 --- --- --- --- --- --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*25011 TC- --- --- -C- TAC --- --- T-- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*25012 TC- --- --- -C- TAC --- --- T-- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2601 -C- --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2701 --- --- --- --- --- --- --- --- --- --- --- -TC GGT --* *** *** *** *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2702 --- --- --- --- --- --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2703 --- --- --- --- --- --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2704 --- --- --- --- --- --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2705 -C- --- --- --- --- --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2706 --- --- --- --- --- --- --- --- --- --- --- -TC G-- *** *** *** *** *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2801 --- --- --- -C- TAC --- --- --- --- --- --- --C G-- --- --- --- --- --- --- --- --- - -- --A --- -T- --- --- --- *** *** *** *** *** DRB3*2802 --- --- --- -C- TAC --- --- --- --- --- --- --C G-- *** *** *** *** *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*2901 T-T --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3001 -C- --- --- -C- TAC --- --- T-- --- --- --- -TC GGT --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3002 -C- --- --- -C- TAC --- --- --- --- --- --- --C G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3101 --- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- --- --- --- --- --- DRB3*3201 T-T --- --- -C- TAC --- --- --- --- --- --- -TC GGT --- --- --- --- --- --- --- --- - -- --- --- -T- --- --- --- --- --- --- --- --C DRB3*3202 T-T --- --- -C- TAC --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3301 -C- --- --- -C- TAC --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3401 A-T --- --- -C- TAC --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3402 A-T --- --- -C- TAC --- --- --- --- --- --- -TC G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3501 A-T --- --- -C- TAC --- --- --- --- --- --- -TC T-T --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3601 T-T --- --- -C- TAC --- --- --- --- --- --- --C G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3701 TC- --- --- -C- TAC --- --- T-- --- --- --- -TC GGT *** *** *** *** *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3801 A-T --- --- -C- TAC --- --- --- --- --- --- -TC G-- *** *** *** *** *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*3901 T-T --- --- -C- TAC --- --- --- --- --- --- -TC GGT *** *** *** *** *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB3*4001 --- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** DRB1*0101 -T- --- --- -C- T-C --- --- T-- --- --- T-- AT- GG- --- --C --- -TC C-- --- -A- -A- - -- --- --- --- --- --- --- --- --- --- --- --C DRB1*0201 -T- --- --- -C- T-C --- --- T-- --- --- T-- AT- GGT --- --C --- -TG --- --- -A- -A- - -- --- --- --- --- --- --- --- --- --- --- --C DRB2*0101 A-- --- --- -C- T-- --- --- -C- --- --- CA- --C --T -GT --- C-- T-G AG- --- --C --- - -- --- --- --- --- --- --- --- --- --- --- --C 110 120 130 140 DRB3*0102 CAG CCC CTG CAG CAC CAC AAC CTC CTG GTC TGC TCT GTG AAC GGT TTC TAC CCA GGC CAC ATT GAA GTC AGG TGG TTC CGG AAC GGC CAT GAA GAG GAG GCT DRB3*0101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -C- --- --- --- --- --- DRB3*1601 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- A-- --- --- --- --- --- --- --- --T --- --- --- --- --- --- DRB3*3101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*3201 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --T --- --- --- --- --- --- DRB1*0101 --- --T --- --- --- --- --- --- --- --- --- --- --- --T --- --- --T --- --A --- G-- --- --- --- --- --- -A- --- --- --- --- --- ... --- DRB1*0201 --- --T --- --- --- --- --- --- --- --- --- --- --- --T --- --- --T --- --A --- --- --- --- --- --- --- -A- --- --- --- --- --- ... --- DRB2*0101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 150 160 170 DRB3*0102 GGG GTG ATC TCC ACA GGC CTG ATC CAG AAT GGA GAC TGG ACC TTC CAG ACC ATG GTG ATG CTT GAA ACA GTT CCT CAG AGT GGA GAG GTC TAC ACC TGC CAA DRB3*0101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*1601 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*3101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*3201 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB1*0101 --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- DRB1*0201 --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- --- --- DRB2*0101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 180 Exon 4 200 DRB3*0102 GTG GAT CAC CCC AGC CGG ACG AGC CCT ATC ACA GTA GAA TGG A GG GCA CGG TCT GAC TCT GCT CAG AGC AAG ATG ATG AGT GGA GTC GGG GGC TTC GTT DRB3*0101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*1601 --- --G --- --- --- -A- --A --- --- --- --- --- --- --- - -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*3101 --- --- --- --- -AG --- --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB3*3201 --- --G --- --- --- A-- --A --- --- --- --- --G --- --- G -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DRB1*0101 --- --G --- --- --- --- --- --- --- C-- --- --G --- --- - -- --- T-A --- --- --- --- --- --- -G- --- --- --- --- --- A-- --- --T --- DRB1*0201 --- -GG --- --- --- --- --- --- --- --- --- --- --- --- - -- --- T-A --- --- --- --- --- --- -G- --- --- --- --- --- A-- --- --T --- DRB2*0101 --- --G --- --- --- T-- --- --- --- C-- --- --G --- --- - -A --- -A- --- --- --- --- --- --G --- C-- --- --- --- A-- --A --- --T --- 210 220 0 Exon 5 230 Exon 6 DRB3*0102 CTG GGT CTG CTC TTC CTT GCC GTG GGG CTC TTC ATC TAC TTC AGG AAT CAG AAA G GA CGC CCT ACA CTT CAG CCA ACA G GG CTC CTG AGC TGA DRB3*0101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - ** *** *** *** *** *** *** *** * ** *** *** *** *** DRB3*1601 --- --- --- T-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- --- - -- --- --- --- --- DRB3*3101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- --- - -- --- --- --- --- DRB3*3201 --- --- --- --- --- --- --G --- --- --- --- --- --- --- --- --- --- --- - ** *** *** *** *** *** *** *** * ** *** *** *** *** DRB1*0101 G-- --- --- --- --- --- -GG A-C A-- T-G --- --- --- --T --- --- --- --- - ** *** *** *** *** *** *** *** * ** *** *** *** *** DRB1*0201 --- --- --- --- --- --- -GG A-C A-- T-G --- --- --- --T --- -.- --- --- - ** *** *** *** *** *** *** *** * ** *** *** *** *** DRB2*0101 --- --- --- --- --- --- -G- --- --A --G --- --- C-- C-- --- -G- A-- --- - ** *** *** *** *** *** *** *** * ** *** *** *** ***

Please Note: In the DRB1 sequences, the symbol $ indicates that the extra codon ATA is found in the DRB1*0101 allele after codon 33, while # indicates an extra GAT codon in both DRB1*0101 and DRB1*0201 after codon 72.

DQA sequences

Exon 1 1 Exon 2 10 DQA*0101 ATG ATC CTG AAC AGA GCC CTG ATT TGG GGG GCC CTC GCC CTG ACC ACC ATG ATG GGT CCC TCT GGG AGT GAA GAC ATT GTG G CT GAC CAC ATT GGC GCC DQA*0102 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- --- DQA*0103 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --T --- DQA*0201 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** --- - -- --- --- --- --- CG- DQA*0202 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *-- --- DQA*0203 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- --- DQA*0204 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --T --- DQA*0301 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- --- DQA*0302 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** --- DQA*0401 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- --- DQA*0501 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** --- DQA*0801 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- --- DQA*0802 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- --- DQA*10011 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- A-- DQA*10012 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- A-- DQA*1101 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- --- DQA*12011 --- G-- --- --- --- --- --- --- -T- --- --- --- --- --- --- --- --- --- A-- --- --- --- --- --- --- --- --- - -- --- --- --- --- A-- DQA*12012 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *-- A-- DQA*12021 --- --- --- --- --- --- --- --- -T- --- --- --- --- --- --- --- --- --- A-- --- --- --- --- --- --- --- --- - -- --- --- --- --- A-- DQA*12022 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- A-- DQA*1203 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * -- --- --- --- --- A-- DQA*1301 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *-- --- DQA*1302 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** --- DQA*1401 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- --- DQA*2001 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** T-- DQA*2002 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- G-- --- T-- DQA*2101 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- G-- --- T-- DQA*2201 --- G-- --- --- --- --T --- --- CT- --- --- --- --- --- --- --- --- --- A-C --- AA- --A G-- --- --- --- --- - -- --- --- G-- --- T-- DQA*22021 --- G-- --- --- --- --T --- --- CTA --- --- --- --- --- --- --- --- --- A-C --- AG- --A G-- --- --- --- --- - -- --- --- G-- --- T-- DQA*22022 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** T-- DQA*22023 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- G-- --- T-- DQA*22031 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- G-- --- T-- DQA*22032 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** T-- DQA*2204 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- G-- --- T-- DQA*2205 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** T-- DQA*2301 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** T-- DQA*2401 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- G-- --- T-- DQA*25011 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- G-- --- A-T DQA*25012 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- G-- --- A-T DQA*2502 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- G-- --- A-T DQA*2601 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** A-T DQA*2602 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** A-T DQA*2603 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** A-T DQA*27011 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** --- --- --- --- A-- DQA*27012 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *** A-- DQA*2702 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * -- --- --- --- --- A-- DQA*2801 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * ** *** *** *** *-- AT- 20 30 40 DQA*0101 TAT GGC ATA AAC GTC TAC CAC ACA TAT GGT CCC TCT GGC TAC TAT ACC CAT GAA TTT GAT GGA GAT GAA GAG TTC TAC GTG GAC CTG GAA AAG AGG GAG ACT DQA*0102 --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0103 --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0201 --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0202 --- --- --- --- G-- --- --- --- --- --- --- --- --- --- -T- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0203 --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0204 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0301 --- --- --- --- G-- --- --- T-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0302 --- --- --- --- G-- --- --- T-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0401 --- --- --- --- G-- --- --- T-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0501 --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0801 --- --- --- --- G-- --- --- T-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --- --- --- --- --- DQA*0802 --- --- --- --- G-- --- --- T-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --- --- --- --- --- DQA*10011 --- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- --- DQA*10012 --- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*1101 --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*12011 --- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*12012 --- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*12021 --- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*12022 --- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*1203 --- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*1301 --- --- --- --- G-- --- --- T-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --- --- -A- --- --- DQA*1302 --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --- --- -A- --- --- DQA*1401 --- --- --- --- G-- --- --- T-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*2001 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G AT- --T --T --- --- --- -GG --- -A- --- --- DQA*2002 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G AT- --T --T --- --- --- -GG --- -A- --- --- DQA*2101 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G AT- --T --T --- --- --- -GG --- -A- --- --- DQA*2201 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G AT- --T --T --- --- --- -GG --- -A- --- --- DQA*22021 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G AT- --T --T --- --- --- -GG --- -A- --- --- DQA*22022 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G AT- --T --T --- --- --- -GG --- -AA --- --- DQA*22023 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G AT- --T --T --- --- --- -GG --- -AA --- --- DQA*22031 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G CT- --T --T --- --- --- -GG --- -AA --- --- DQA*22032 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G CT- --T --T --- --- --- -GG --- -A- --- --- DQA*2204 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G AT- --T --T --- --- --- -GG --- -A- --- --- DQA*2205 --C --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --G --- --- --- --- --C --G AT- --T --T --- --- --- -GG --- -A- --- --- DQA*2301 --- --- --- G-- T-- --- --A T-T C-- --- --- --- --- C-G --C -T- --- --- --- --- --- --C --G AT- --T --T --- --T --- -GG --- -A- --- --- DQA*2401 --- --- -C- G-G --- --- --A T-T C-- --- --- --- --- C-G --C --- --C --- --- --- --- --C --G CT- --T --T --- --- --- -GG --- -A- --- --- DQA*25011 --- --- -C- G-- T-- --- --A T-T C-- --- --T --- --- C-G --C -T- --C C-- --- --- --- --C --G --- --T --T --- --- --- --G --- GAA --- G-- DQA*25012 --- --- -C- G-- T-- --- --A T-T C-- --- --T --- --- C-G --C -T- --C C-- --- --- --- --C --G --- --T --T --- --- --- --G --- GAA --- G-- DQA*2502 --- --- GC- G-- T-- --- --A T-T C-- --- --- --- --- C-G --C -T- --C C-- --- --- --- --C --G --- --T --T --- --- --- --G --- GAA --- G-- DQA*2601 --- --- -C- G-- T-- --- --A T-T C-- --- --T --- --- C-G --C -T- --C C-- --- --- --- --C --G --- --T --T --- --- --- --G --- GAA --- G-- DQA*2602 --- --- -C- G-- T-- --- --A T-T C-- --- --T --- --- C-G --C -T- --C C-- --- --- --- --C --G --- --T --T --- --- --- --G --- GAA --- G-- DQA*2603 --- --- -C- G-- T-- --- --A T-T C-- --- --T --- --- C-G --C -T- --C C-- --- --- --- --C --G --- --T --T --- --- --- --G --- GAA --- G-- DQA*27011 --C --T GC- G-- T-- --- --A T-T C-- --- --- --- --- C-G --C -T- --- --- --- --- --- --- --G TT- --T --T --- --- --- -GG --- -A- --- --- DQA*27012 --- --- GC- G-- T-- --- --A T-T C-- --- --- --- --- C-G --C -T- --C --- --- --- --- --C --G TT- --T --T --- --- --- -GG --- -A- --- --- DQA*2702 --- --- GC- G-A T-- --- --A T-T C-- --- --- --- --- C-G --C -T- --C --- --- --- --- --- --G TT- --T --T --- --- --- -GG --- -A- --- --- DQA*2801 --- --- --- -G- --A --T --G T-T --- --- --- --- --- C-G --C --- --- --- --- --- --- --- --G C-- --- --T --- --- --- --G --- -A- --- --- 50 60 70 DQA*0101 GTC TGG CGT CTG CCT GTG TTT AGT AAA TTT ACA AGT TTT GAC CCT CAG GGT GCG CTG AGA AAC ATA GCT ACA GCG AAG CAC AAT TTG GAG GTC TTG ATT CAA DQA*0102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- --- --- --- --- --- A-- --- --- --- DQA*0103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G A-- --- --- --- --- --- A-- A-- --- -G- DQA*0201 --- --- AA- --- --- C-- --- --- --- --- -G- C-- --- --- --- --- --- --- --- --- --- --- --- --- -T- --- --- --- --- --- A-- G-- --- --- DQA*0202 --- --- AA- --- --- C-- --- --- --- --- -G- C-- --- --- --- --- --- --- --- --- --- --- --- --- -T- --- --- --- --- --- A-- G-- --- --- DQA*0203 --- --- AA- --- --- C-- --- --- --- --- -G- C-- --- --- --- --- --- --- --- --- --- --- --- --- -T- --- --- --- --- --- A-- G-- --- --- DQA*0204 --- --- AA- --- --- C-- --- --- --- --- -G- C-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- A-- G-- --- --- DQA*0301 --- --- AA- --- --- C-- --- --- --- --- -G- C-- --- --- --- --- --- --- --- --- --- --- --- --G A-- --- --- --- --- --- A-- A-- --G --- DQA*0302 --- --- AA- --- --- C-- --- --- --- --- -G- C-- --- --- --- -G- --- --- --- --- --- --- --- --G A-- --- --- --- --- --- A-- A-- --G --- DQA*0401 --- --- AA- --- --- C-- --- --- --- --- -G- C-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*0501 --- --- AA- --- --- C-- --- --- --- --- -G- C-- --- --- --- --- --- --- --- --- --- --- --- --- -T- --- --- --- --- --- A-- G-- --- --- DQA*0801 --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- A-T A-- --- --- DQA*0802 --- --- --- --- -A- --- --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- A-T A-- --- --- DQA*10011 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- -T- --- --- --- --- --- A-- G-- --- --- DQA*10012 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- -T- --- --- --- --- --- A-- G-- --- --- DQA*1101 --- --- --- --- --- --- --- --- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --G AT- --- --- --- --- --- A-- G-- --- --- DQA*12011 --- --- --- --- --- --- --- --- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --G A-- --- --- --- C-- --- A-- G-- --- --- DQA*12012 --- --- --- --- --- --- --- --- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --G A-- --- --- --- --- --- A-- G-- --- --- DQA*12021 --- --- --- --- --- --- --- --- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --G AT- --- --- --- --- --- A-- G-- --- --- DQA*12022 --- --- --- --- --- --- --- --- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --G AT- --- --- --- --- --- A-- G-- --- --- DQA*1203 --- --- --- --- --- --- --- --- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- --G T-- --- --- G-- --- --- --- --- --- --- DQA*1301 --- --- --- --- --- --- --- --- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- GTG -G- --A --G -C- --- --- --- A-- --- -G- DQA*1302 --- --- --- --- --- --- --- --- --- --- G-- -C- --- --- --- --- --- --- --- --- --- --- --- GTG -G- --A --G -C- --- --- --- A-- --- -G- DQA*1401 --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- GTG -G- --A -GG -C- --- --- --- A-- --- -G- DQA*2001 --- --- A-G --- --- AGT --- --C C-G --- G-- G-- --- --- --A --A -C- --A --- --T G-A --- --- --- T-A --A --- --C --- --T --- C-- -C- A-- DQA*2002 --- --- A-G --- --- AC- --- --C C-G --- G-- G-- --- --- --A --- -C- --A --- --T G-A --- --- --- T-A --A --- --C --- --T --- C-- -C- A-- DQA*2101 --- --- A-G --- --- A-T --- --C C-G --- G-- G-- --- --- --A --- TT- --A --- --T G-A --- --- --- T-A --A --- --C --- --T --- C-- -C- A-- DQA*2201 --- --- A-G --- --- A-- --- --C C-G --- G-- G-- --- --- --A --- -C- --A --- --T G-A --- --- --- T-A --A --- --C --- --T --- C-- -C- A-- DQA*22021 --- --- A-G --- --- A-- --- --C C-G --- G-- G-- --- --- --A --- -C- --A --- --T G-A --- --- --- --A --A --- --C --- --T --- C-- -C- A-- DQA*22022 --- --- A-A --- --- A-- --- --C C-G --- G-- G-G --- --- --A --- -C- --A --- --T G-A --- --- --- --A --A --- --C --- --T --- C-- -C- A-- DQA*22023 --- --- A-G --- --- A-- --- --C C-G --- G-- G-G --- --- --A --- -C- --A --- --T G-A --- --- --- --A --A --- --C --- --T --- C-- -C- A-- DQA*22031 --- --- A-G --- --- A-- --- --C C-G --- G-- G-G --- --- --A --- -C- --A --- --T G-A --- --- --- --A --A --- --C --- --T --- C-- -C- A-- DQA*22032 --- --- A-G --- --- A-- --- --C C-G --- G-- G-G --- --- --A --- -C- --A --- --T G-A --- --- --- --A --A --- --C --- --T --- C-- -C- A-- DQA*2204 --- --- A-G --- -T- A-- --- --C C-G --- G-- G-- --- --- --A --- -C- --A --- --T G-A --- --- --- --A --A --- --C --- --T --- C-- -C- A-- DQA*2205 --- --- A-G --- --- A-- --- --C C-G --- G-- G-- --- -C- --A --- -C- --A --- --T G-A --- --- --- T-A --A --- --C --- --T --- C-- -C- A-- DQA*2301 --- --- A-G --- --- A-- --- G-- G-- --A --- G-- --- --- --G --A --- --A --- --G --- --- --- --- -AA --A --- --C --- --T A-- --- -C- A-- DQA*2401 --- --- A-G --- --- A-- --- G-- G-T --A --- --- --- --- --A --- --- --A --- --T G-A --- --- --- T-A --A --- --- --- --T A-- C-- -C- AG- DQA*25011 --- --- A-G --- --- A-- --- GA- --- --A ... C-- --C C-- --G --A --- --A --- --- --- --- --- -T- --- --A --- --C --- --T --T C-- -CA A-G DQA*25012 --- --- A-G --- --- A-- --- GA- --- --A ... C-- --- C-- --G --A --- --A --- --- --- --- --- -T- --- --A --- --C --- --T --T C-- -CA A-- DQA*2502 --- --- A-G --- --- A-- --- GA- --- --A ... C-- --- C-- --G --A --- --A --- --- --- --- --- -T- --- --A --- --C C-- --T --T C-- -CA A-- DQA*2601 --- --- A-G --- --- A-- --- GA- --- --A -G- C-- --- C-- --G --A --- --A --- --- G-- --- --- GT- --- --A --- --C --- --T --- C-- -C- A-- DQA*2602 --- --- A-G --- --- A-- --- GA- --- --A -G- C-- --- C-- --G --A --- --A --- --- --- --- --- GT- --- --A --- --C --- --T --- C-- -C- A-- DQA*2603 --- --- A-G --- --- A-- --- GA- --- --A -G- C-- --- C-- --G --A --- --A --- --- --- --- --- -T- --- --A --- --C --- --T --T C-- -CA A-- DQA*27011 --- --- -AG --- --- A-- --- G-- G-- --A --- --- --- --A G-A --A -A- --- --- -AT G-A --- --- -A- --A --A --- -CC --- --T --- C-- -C- A-- DQA*27012 --- --- -AG --- --- A-- --- G-- G-- --A --- --- --- --A G-A --A -A- --- --- -AT G-A --- --- -A- --A --A --- -CC --- --T --- C-- -C- A-- DQA*2702 --- --- -AG --- --- A-- --- G-- G-- --A --- --- --- --A G-A --A -A- --- --- -AT G-A --- --- -A- --A --A --- -CC --- --T --- C-- -C- A-- DQA*2801 -C- --- -AG --- --C C-A --- --C -G- A-G TT- --- --- --- --A --- TTA --A --- --- --- --- --- -TC AT- --A -TT C-- G-- --C T-- C-- -C- A-- 80 Exon 3 90 100 110 DQA*0101 AGG TCC AAC TCT ACT GCT GCT ACC AAC A AG GTT CCT GAG ATG ACT GTG TTT CCC AAG TCT CCT GTA ATG CTG GGC CAG CCC AAC ACC CTC ATC TGT CAC DQA*0102 --- --- --- --- --- --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*0103 --- --- --- --- --- --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*0201 --- --- --- --- --- --- --- --- --- - -- --- --- --A G-- --- --- --- T-- --- --- --C A-G --- --- --- --- --- --- --- --- --- --- --- DQA*0202 --- --- --- --- --- --- -** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*0203 --- --- --- --- --- --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*0204 --- --- --- --- --- --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*0301 --- --- --- --- --- --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*0302 G-- --- --- --- --* *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*0401 --- --- --- --- --- A-- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*0501 --- --- --- --- --- *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*0801 GA- --- --- --- --- --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*0802 GA- --- --- --- --- --- T-- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*10011 --- --- --- --- --- --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*10012 --- --- --- --- --- --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*1101 --- --- --- --- --- --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*12011 --- --- --- --- --- --- --- --- --- - -- --- --- --- G-- --- --- --- T-- --- --- --C --G --- --- --T --- --- --- --T --- --- --- --T DQA*12012 --- --- --- --- --- --- -** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*12021 --- --- --- --- --- --- --- --- --- - -- --- --- --- G-- --- --- --- T-- --- --- --C --G --- --- --T --- --- --- --T --- --- --- --T DQA*12022 --- --- --- --- --A --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*1203 --- --- --- --- --- --- --- --- --- - -- --- --- --- G-- --- --- --- T-- --- --- --C --G --- --- --T --- --- --- --T --- --- --- --T DQA*1301 --- --- --- --- --- --- -** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*1302 --- --- --- --- --* *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*1401 --- --- --- --- --- --- --- --- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2001 C-C --- --- -T- --* *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2002 C-C --- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2101 C-C --- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2201 C-C --- --- -T- --C C-- -T- -T- --T G -- --- --A --- G-- --- --- --- T-- --- --- --C --G --C --- A-T --- --- --- --- --- --- --- --- DQA*22021 C-C --- --- -T- --C C-- -T- -T- --T G -- --- --A --- G-- --- --- --- T-- --- --- --C --G --- --- --T --- --- --- --- --- --- --- --- DQA*22022 C-C --- --- -T- --* *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*22023 C-C --- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*22031 C-C --- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*22032 C-C --- --- -T- --* *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2204 C-C --- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2205 C-C --- --- -T- --* *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2301 T-C --- --- -T- --* *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2401 C-C --- --- -T- --C C-- --C -T- --- * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*25011 CTC -A- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*25012 CTC -A- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2502 CTC -A- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2601 C-C -A- --- -T- --* *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2602 C-C -A- --- -T- --* *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2603 CTC -A- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*27011 C-C --- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*27012 C-C --- --- -T- --* *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2702 C-C --- --- -T- --C C-- -T- -T- --T * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DQA*2801 TTC --- --- --- --- --- -** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** 120 130 140 DQA*0101 GTG GAC AAC ATC TTT CCT CCT GTG ATC AAC ATT ACA TGG TTG AGG AAC GGG CAC TTG GTC ATA GAG GGT ATT TCT GAG ACC AGC TTC CTC TCC AAG GAT GAT DQA*0201 --- --- --- --- --- --- --- --- --- --- --- --- --- C-- -A- --- --- --- --- --- --- --- --- --- --- --G --- --- --- --- --- --- --- --- DQA*12011 --- --- --- --- --- --C --- --- --- --- --C --- --- --- --- --T --- --- -C- --- -C- --- --A G-- --- --G --- --T --T --- AT- --- AG- --- DQA*12021 --- --- --- --- --- --C --- --- --- --- --C --- --- --- --- --T --- --- -C- --- -C- --- --A G-- --- --G --- --T --T --- AT- --- AG- --- DQA*1203 --- --- --- --- --- --C --- --- --- --- --C --- --- --- --- --T --- --- -C- --- -C- --- --A G-- --- --G --- --T --T --- AT- --- AG- --- DQA*2201 --- --- --- --T --- --C --- --- --- --- --- --- --- C-- -A- --T --- --T GCA --- -C- --- --- G-- --- --G --- --- --- --- C-T --- --- --- DQA*22021 --- --- --- --T --- --C --- --- --- --- --- --- --- C-- -A- --- --- --T GCA --- -C- --- --- G-- --- --G --- --- --- --- C-T --- --- --- 160 170 DQA*0101 CAT TCC TTC GCC AAG ATC AGT TAC CTC ACC TTC CTT CCT TCT GAT GAT GAT GTT TAT GAC TGC AAA GTG GAG CAC TGG GGC CTG GAT AAG CCA CTG CTA AAA DQA*0201 --- --- --- T-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- DQA*12011 T-- --T --T CT- --- --- -A- --T --- --- --- --C --- --- --- --- --C --- --- --- --- --- --- --- --- --- --T --- --- G-- --- --T --G --- DQA*12021 T-- --T --T CT- --- --- -A- --T --- --- --- --C --- --- --- --- --C --- --- --- --- --- --- --- --- --- --T --- --- G-- --- --T --G --- DQA*1203 T-- --T --T CT- --- --- -A- --T --- --- --- --C --- --- --- --- --C --- --- --- --- --- --- --- --- --- --T --- --- G-- --- --T --G --- DQA*2201 --- --T --- CT- --- --T G-- --T --- --- --- --C --- --- --- A-- --C A-- --- --- --- --- --- --- --- --- --T --- --- G-- --- --T --G --- DQA*22021 --- --T --- CT- --- --T G-- --T --- --- --- --C --- --- --- A-- --C A-- --- --- --- --- --- --- --- --- --T --- --- G-- --- --T --G --- 180 Exon 4 190 200 210 DQA*0101 CAC TGG G AA CCT GAG ATT CCA GCC CCT ATG TCA GAG CTG ACA GAG ACT GTG GTC TGT GCC TTG GGG TTG ACC GTG GGC CTC GTG GGC ATC GTG GTG GGC DQA*0201 --- --- - -- --- --T --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*12011 --- --- - -G --- --T --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --- --- --- --- A-- --- --- DQA*12021 --- --- - -G --- --T --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --- --- --- --- A-- --- --- DQA*1203 --- --- - -G --- --T --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --- --- --- --- A-- --- --- DQA*2201 --- --- - -G --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --T --- --T --- --- --- --- DQA*22021 --- --- - -G --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --T --- --T --- --- --- --- 220 230 DQA*0101 ACT GTC CTC ATC ATC CGA GGT CTG CGC TCA GGT GGC CCC TCC AGA CAC CAG GGG CCG TTG TGA DQA*0201 --- --- --- --- --- --- --- --- --- --- --C --- --- --- --- G-- --- --- --- --- --- DQA*12011 --C A-- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*12021 --C A-- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*1203 --C A-- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQA*2201 --C A-- T-- --- --- -A- --C --- --- --- --- --G A-- --- --- --- --- --T --C --- --- DQA*22021 --C A-- T-- --- --- -A- --C --- --- --- --- --G G-- --- --- --- --- --T --C --- ---

DQB sequences

Exon 1 1 DQB*1001 ATG TTT GGG ATG GTG GCT CTG CGG ATC CCC AGA GCC CTC TGG ACA GCA GTT GTG ATG GTG ACC CTG GTG ATG CTG AGC ACC CCA GGG GCC GAG GGC AGA GAC DQB*1003 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** **- --- --- DQB*1007 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --T --- --- --- --- DQB*0101 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** **- --- --- DQB*0102 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** **- --- --- DQB*02011 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *-- --- --- --- --- --- --- --- --- --T --- --- --- --- DQB*0902 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** **- --- --- DQB*1101 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** **- --- --- DQB*1301 --- -C- --- --- --- --- T-- --- --- --- --- -G- --T --- --- --- -C- --- --- --- --- --- -C- G-- --- --- --- --- --- A-T --- --- --- --- Exon 2 10 20 30 DQB*1001 TCA CCA A AG GAT TTC GTG TAC CAG TTT ATG GGC CAG TGT TAT TTC ACC AAC GGG ACG GAG CGG GTG CGG TAC GTG ACC AGA TAC ATC TAC AAC CAG GAG DQB*10021 *** *** * ** *** *** *** --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*10022 *** *** * ** *** *** **- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1003 --- --- - -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1004 *** *** * ** *** *** *** --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1005 *** *** * ** *** *** *** -T- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1006 *** *** * ** *** *** *** GT- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1007 --- --- - -- --- --- --- GT- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1008 *** *** * ** *** *** **- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0101 --G --- - -- --- --- --- --- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0102 --- --- - -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0103 *** *** * ** *** *** *** --- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- DQB*02011 --- --- - -- --- --- --- --- --- --- -A- T-- -T- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*02012 *** *** * ** *** *** *** --- --- --- -A- T-- -T- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0301 *** *** * ** *** *** *** -T- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- CT- --- --- --- A-- --A --- --- --- --- DQB*0401 *** *** * ** *** *** *** GT- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0402 *** *** * ** *** *** *** --- --- --- -A- T-- -T- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0501 *** *** * ** *** *** *** --- --- -A- -A- --- -T- --- --C --- --- --- --- --- C-- --- --- --- CT- --- --- --- --- --- --- --- -G- --- DQB*0502 *** *** * ** *** *** --- --- --- -A- -A- --- -T- --- --C --- --- --- --- --- C-- --- --- --- CT- --- --- --- --- --- --- --- -G- --- DQB*06011 *** *** * ** *** *** --- --- --- --- --A TA- --- --- --C --- --- --T --- --A --- --- --- --- AGT --- -AA -A- C-G --- --- --- -G- C-A DQB*06012 *** *** * ** *** *** *** --- --- --- --A TA- --- --- --C --- --- --T --- --A --- --- --- --- AGT --- -AA -A- C-G --- --- --- -G- C-A DQB*0701 *** *** * ** *** *** C-- GT- --- --- C-- --- --- --- --C --- --- --- --- --- --- --- --C --- GGT --- --- --- --- --- --- --- -G- --- DQB*0801 *** *** * ** *** *** *** AT- --- --- -A- T-- -T- --- --C --- --- --- --- --- --- --- --- -A- --- --- --- --- C-- --- --- --- --- --A DQB*0901 *** *** * ** *** *** *** GT- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --A --- --- CT- --- GT- --- C-- --- --- --- -G- --- DQB*0902 --G --- C -- --- --- --- GT- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --A --- --- CT- --- GT- G-- C-- --- --- --- -G- --- DQB*0903 *** *** * -- --- --- --- GT- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --A --- --- CT- --- GT- --- C-- --- --- --- -G- --- DQB*1101 --G --- C -- --- --- --- -T- -G- --- -A- --- -T- --- --C --- --- --- A-- --- --- --- --- --- --- --- --- --- --- -C- --- --- --- --- DQB*1201 *** *** * ** *** *** *** -T- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- AGT --- -A- --- --- --- --- --- -G- --- DQB*1301 --G --- C -- --- --- --- -T- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- AGT --- --- --- --- --- --- --- -G- --- DQB*1401 *** *** * ** *** *** *** GT- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- AGT --- -A- --- --- --- --- --- --- --- DQB*1402 *** *** * ** *** *** **- --- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- AGT --- -A- --- --- --- --- --- -G- --- DQB*1501 *** *** * ** *** *** --- --- --- --- -A- T-- -T- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1601 *** *** * ** *** *** --- --- --- -A- -A- --- -T- --- --C --- --- --- --- --- C-- --- --- --- CT- --- --- --- --- --- --- --- -G- --- DQB*1701 *** *** * ** *** *** --- GT- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- CT- --- --- --- C-- --- --- --- -G- --- DQB*1702 *** *** * ** *** *** *** *T- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- CT- --- --- --- C-- --- --- --- -G- --- DQB*1801 *** *** * -- --- --- --- CT- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- AGT --- -A- --- --- --- --- --- --- --- DQB*1802 *** *** * ** *** *** *** GT- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --- --- --- --- DQB*1901 *** *** * ** *** *** *** GT- --- --- -A- --- -T- --- --C --- --- --- --- --- --- --- --C --- GGT --- --- --- --- --- --- --- --- --- DQB*2001 *** *** * ** *** *** *** GT- --C --- --- --- --- --- --C --- --T --T --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*2101 *** *** * ** *** *** **- -TT -T- --- --- --- --- --- --C --- --- --- --- --- --- --- --- --- CT- --- --- --- --- --- --- --- --- --- 40 50 60 DQB*1001 GAG TAC GCG CGC TTC GAC AGC GAC TGG GAC GAG TAC CGG GCG CTG ACC CCG CTG GGG CGG CCG GCC GCC GAG TAC TGG AAC AGC CAG AAG GAC ATC CTG GAG DQB*10021 --- --- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*10022 --- --- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1003 --- --- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- DQB*1004 --- -T- --- --C --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1005 --- -T- --- --C --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- -A- --- --- CT- --- --- --- --- --- --- --- --- --- DQB*1006 --- --- --- --C --- --- --- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1007 --- --- --- --C --- --- --- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1008 --- --- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -G- DQB*0101 --- A-- -T- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- -A- --- --- --- -TC --- --- --- --- --- T-- --- --- DQB*0102 --- A-- -T- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- -A- --- --- --- -TC --- --- --- --- --- T-- --- --- DQB*0103 --- A-- -T- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- DQB*02011 --- --- -T- --- --- --- --- --- GT- -G- --- --- --- --- G-- --- --- --- --- --- --- C-- --- --- C-- --- --- --- --- --- --- T-- --- --- DQB*02012 --- --- -T- --- --- --- --- --- GT- -G- --- --- --- --- G-- --- --- --- --- --- --- C-- --- --- C-- --- --- --- --- --- --- T-- --- --- DQB*0301 --- --- -T- --- --- --- --- --- --- -G- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- C-- --- --- DQB*0401 --- A-- -T- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0402 --- A-- -T- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0501 --- -T- --- --- --- --- --- --- GT- A-- --- -T- --- --- G-- --- --A --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0502 --- -T- --- --- --- --- --- --- GT- A-- --- -T- --- --- G-- --- --A --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- DQB*06011 --A C-- -T- --A --- --- --- --- GT- A-- --- -T- --- --- G-T T-- --- --- --- -A- -G- -A- --- --- --- -TC --T --- --C ... --- T-- --- A-- DQB*06012 --A C-- -T- --A --- --- --- --- GT- A-- --- -T- --- --- G-T T-- --- --- --- -A- -G- -A- --- --- --- -TC --T --- --C ... --- T-- --- A-- DQB*0701 --- --- -T- --C --- --- --- --- GT- A-- --- --- --- --- G-- --- --- --- --- --- --- T-- --- --- --- --- --- --- --- G-- --- --- --- --- DQB*0801 --- -T- AT- --C --- --- --- --A GT- -G- --- --- --- --- G-- --T --- --A --- --- -G- CAA A-- --- --- -TC --- --- --- --- --- GAA --- --- DQB*0901 --- --- --- --- --T --- --- --- GT- A-- --- --- --- --- G-- --- --T --- --- --- --- -A- --- --- --- --- --- --- --- --- --- C-- --- --- DQB*0902 --- --- --- --- --T --- --- --- GT- A-- --- --- --- --- G-- --- --T --- --- --- --- -A- --- --- --- --- --- --- --- --- --- C-- --- --- DQB*0903 --- --- --- --- --T --- --- --- GT- A-- --- --- --- --- G-- --- --T --- --- --- --- CA- --- --- --- --- --- --- --- --- --- C-- --- --- DQB*1101 --- A-- -T- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- T-- --- --- --- -TC --- --- --- G-- --- C-- --- --- DQB*1201 --- --- -T- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- -A- --- --- --- -TC --- --- --- --- --- T-- --- --- DQB*1301 --- --- -T- --- --- --- --- --- GT- A-- --- --- --- --- G-- --- --A --- --- --- --- T-- --- --- --- -TC --- --- --- G-- --- C-- --- --- DQB*1401 --- --- -T- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1402 --- --- -T- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1501 --- A-- -T- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- C-- --- --- DQB*1601 --- --- --- --- --- --- --- --- --- --- --- --- --- -T- G-- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- C-- --- --- DQB*1701 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1702 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1801 --- --- -T- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1802 --- --- -T- --- --- --- --- --- --- --- TT- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1901 --- --- -T- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -AA --- --- --- --- --- --- --- --- --- T-- --- --- DQB*2001 --- AC- --A TAC -AT --- --T --- GT- -GA --- --- --- --T G-- --- -AA --A --- --- A-T TTG --T --- --T --- --- --- --- --A --T --- --- --- DQB*2101 --- --- -T- --C --- --- --- --- --- -G- --- --- --- --- G-- --G --- -C- --- -A- -G- CAA --- --- --- -TC --- --- --- --- --- T-- --- --- 70 80 90 Exon 3 100 DQB*1001 CGG ACG CGG GCC GAG GTG GAC AGG GTG TGC AGA AAC AAC TAC CAG GTG GAT GCC CCC TTC ACC TGG CAG CGG CAA G TG GAA CCT ACA GTG ACC ATC TCC DQB*10021 --- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*10022 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*1003 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- --- --- --- -T- - -- --- --- --- --- --- --- --- DQB*1004 --- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*1005 --- --- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*1006 -A- --- T-C --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*1007 -A- --- T-- --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- --- DQB*1008 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*0101 -A- --- --- --- --- -C- --- -C- --- --- --- C-- --- --- --- --- --A --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- -T- DQB*0102 -A- --- --- --- --- -C- --- -C- --- --- --- C-- --- --- --- --- --A --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- -T- DQB*0103 --- --- --C --- --- -C- --- -C- --- --- --- C-- --- --- --- --- --A --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*02011 -A- --- --- --- --- --- --- --C --- --- --- C-- --- --- --A C-- --G CT- AT- ACA T-- -T- --- --- -G- - -- --- --- --- --- --- --- --- DQB*02012 -A- --- --C --- --- --- --- --C --- --- --- C-- --- --- --A C-- --G CT- AT- ACA *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*0301 -A- --- --C --- --- --- --- -C- --- --- --- C-- --- --- --- -C- --G CT- AT- ACA *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*0401 --- GT- --C --- --- --- --- --- --- --- --- --- --- --- --- -C- --G CT- AT- ACA *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*0402 --- GT- --C --- --- --- --- --- --- --- --- --- --- --- --- -C- --G CT- AT- ACA *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*0501 -A- -G- --C --- --- --- --- --- --- --- --- C-- --- --- --- C-- --- --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*0502 --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- --- --- --- --- --- --- --- --- --- - -- --- --- --- --- *** *** *** DQB*06011 -A- --- --- --- --- --- --- -C- --- --- --- C-- --- --- --A C-- --G CT- -T- ACA T-- -T- --- --- -G- - -- --- --C --- --- *** *** *** DQB*06012 -A- --- --C --- --- --- --- -C- --- --- --- C-- --- --- --A C-- --G CT- -T- ACA *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*0701 --- GT- --- --- --- --- --- -C- --- --- --- C-- --- --- --A C-- --G CT- AT- ACA T-- -T- --- --- -G- - -- --- --- --- --- *** *** *** DQB*0801 --- GT- --C --- --- -C- --- -CA --- --- --- C-- --- --- --- -C- --G CT- ATT ACA *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*0901 -A- -G- --C --- --- --- --- --- --- --- --- C-- --- --- --- --- -C- --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*0902 -A- -G- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- -C- --- --- --- --- --- --- --- -T- - -- --- --- --- --- --- --- --- DQB*0903 -A- -G- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- -C- --- --- --- --- --- --- --- -T- - -- --- --- --- --- --- --- --- DQB*1101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- -T- DQB*1201 -A- --- --C --- --- -C- --- -C- --- --- --- C-- --- --- --- --- -C- --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*1301 --- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- C-- --- --- --- --- --- --- --- --- --- - -- --- --- --- --- --- --- --- DQB*1401 --- --- --C --- --- -C- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*1402 --- --- --- --- --- -C- --- -C- --- --- --- C-- --- --- --- --- --A --- --- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*1501 -A- --- --- --- --- -C- --- -C- --- --- --- C-- --- --- --- -C- --G CT- AT- ACA T-- -T- --- --- -G- - -- --- --- --- --- *** *** *** DQB*1601 -A- --- --- --- --- --- --- --- --- --- --- C-- --- --- --- --- -C- --- --- --- --- --- --- --- --- - -- --- --- --- --- *** *** *** DQB*1701 -A- -G- --- --- --- --- --- --- --- C-- --- C-- --- --- --- C-- --- --- --- --- --- --- --- --- --- - -- --- --- --- --- *** *** *** DQB*1702 -A- -G- --- --- --- --- --- --- --- --- --- C-- --- --- --- C-- --- --- --- --* *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*1801 -A- --- --- --- --- -C- --- -C- --- --- --- C-- --- --- --- -C- --G CT- AT- ACA T-- -T- --- --- -G- - ** *** *** *** *** *** *** *** DQB*1802 -A- --- --- --- --- -C- --- -C- --- --- --- C-- --- --- --- -C- --G CT- AT- ACA *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*1901 -A- --- --- --- -C- --- --- -C- --- --- --- --- --- --- --- -C- --G CT- AT- ACA *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*2001 -A- --A --- --G --- C-- --- -C- --- --- --- C-- --T --- --- C-- --G -T- AT- ACG *** *** *** *** *** * ** *** *** *** *** *** *** *** DQB*2101 -A- --- --- --- --- -C- --- -C- --- --- --- C-- --- --- --- --- --A --- G-- --- *** *** *** *** *** * ** *** *** *** *** *** *** *** 110 120 130 DQB*1001 CCA TCC AGG ACA GAG GTT CTA AAC CAC CAC AAC CTG CTG GTC TGC TCG GTG ACG GAT TTC TAT CCG GGC CAG ATA AAC GTT CGG TGG TTC CGG AAT GAC CGG DQB*1003 --- --- --- --T --- -C- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- --C --G --- --- C-- --- --- --- --- --- DQB*1007 --G --- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --C --G --- --- --- --- --- --- --- --- DQB*0101 -TG --- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- --- --- --C --G --- --- --- --- --- --- --- -A- DQB*0102 -TG --- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- --- --- --C --G --- --- --- --- --- --- --- -A- DQB*02011 --- --- --- --T --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --C A-- --- --C --G --- --- --- --- --- --- --- --- DQB*0902 --G --- --- --T --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --C --G --- --- --- --- --- --- --- --- DQB*0903 --G --- --- --T --- -C- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- --- --- --C --G --- --- --- --- --- --- --- --- DQB*1101 -TG --- --- --- --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --C --G --- --- --- --- --- --- --- --- DQB*1301 --- --- --- --T --- -C- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --C --G --- --- --- --- --- --- --- --- 140 159 160 170 DQB*1001 GAG GAG ACA GCC GGC GTT GTG TCC ACC CCT CTT ATA GGG AAT GGG GAC TGG ACC TTC CAG ATC CTC GTG ATG CTG GAA ATG ACC CCC CAG CGA GGA GAT GTC DQB*1003 --- --- --- --T --T --- --- --- --- --- --- --T A-- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --* *** DQB*1007 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0101 --- --- --- --T --T --- --- G-- --A --- --- --T A-- --- --- --- --- --- --T --- C-G T-- A-- --- --- --G --- --- --- --- --- --- --* *** DQB*0102 --- --- --- --T --T --- --- G-- --A --- --- -CT A-- --- --- --- --- --- --T --- C-G T-- A-- --- --- --G --- --- --- --- --- --- --* *** DQB*02011 --- --- --- --- --- --- --- --- --- --- --- --T A-A --C --- --- --- --- --- --- --- --- --- --- --- --G --- --- --- --- --- --- --- --- DQB*0902 --- --- --- --T --T --- --- --- --- --- --- --T A-- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --* *** DQB*0903 --- --- --- --T --T --- --- --- --- --- --- --T A-- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1101 --- --- --- --- --- --- --- --- --- --- --- --T A-- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --* *** DQB*1301 --- --- --- --- --- --- --- --- --- --- --- --T A-- --C --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 180 190 Exon 4 200 DQB*1001 TAC ACC TGC CGC GTG GAG CAC CCC AGC CTC CAG AGC CCC ATC ACA GTG GAG TGG C GG GCA CAG TCT GAA TCT GCC CAG AGC AAG ATG CTG AGT GGT GTT DQB*1007 --- --- --- --- --- --- --- --- --- --- --- --- --- --- -TG --- --- --- - -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*02011 --- --- --- --T --- --- --- --- --- --- --- --- --- --- -TG --- --- --- - -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*0903 --- --- --- --- --- --- --- --- --- --- --- --T --- --- T-A --- --- --- - -- --G --- --- --- --- --- --- --- --- --- --- --- --- --- DQB*1301 --- --- --- --T --- --- --- --- --- --- --- --- --- --- T-G --- --- --- - -- --G --- --- --- --- --- --- --- --- --- --- --- --- --- 210 220 Exon 5 230 DQB*1001 GGG GGC TTC GTG CTG GGG CTG ATC TTC CTC GGG CTG GGC CTC ATT ATC CGT CAC AGG AGC CAG AAG G GG CTC ATG CGC TGA DQB*1007 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - -- --- --- --- --- DQB*02011 --A --- --T --- --- --- --- --- --- --T --- --- --- --- --C --- -A- --- --- --- --- --- - -- --- --- --- --- DQB*0903 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - ** *** *** *** *** DQB*1301 --- --- --- --- --- --- --- --- --- --T --- --- --- --- --- --- --- --- --- --- --- --- - -- --- G-- --- ---

DYA Sequences

Exon 2 10 20 30 DYA*01011 CT GAC CAC GTC GGC ACT TAC GGC ACA AAT GTC TAC CAG ACG TAC GGC ACC TCT GGC CAG TTC ACG TTT GAA TTT GAT GGA GAC GAG CTC TTC TAC GTG GAC DYA*01012 -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DYA*0102 -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 40 50 60 DYA*01011 CTG GGG AAA AAG GAG ACT GTC TGG CGG CTG TCC GAG TTT AGC AAT ATC ACC AAG TTT GAA GTT CAG AGC GCC CTG AGA AAC ATT GTT ATG TCA AAA AGA AAT DYA*01012 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- DYA*0102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 70 80 Exon 3 90 100 DYA*01011 TTG GAC ATC TTG ATA AAA AAT TCC AGC TTT ACA CCT GCC ACC AGT G AA ATC CCT GAA GTG GCT GTG TTT CCC AAA TCC TCT GTG GTC CTG GGG ATT CCC DYA*01012 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DYA*0102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** 110 120 130 DYA*01011 AAT ACC CTC ATC TGT CAA GTG GAC AAC ATC TTT CCT CCT GTG ATC AAC ATC ACT TGG TTT TAC AAT GGA CAC TTT GTT GCA GAA GGG ATC GCT GAG ACC ACC DYA*01012 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DYA*0102 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** 140 150 160 DYA*01011 TTC TAC CCC AAG AGT GAC CAC TCT TTC CTC AAG TTC AGT TAC CTC ACC TTT CTT CCC ACC AGT GAA GAC TTC TAT GAC TGC AGA GTG GAG CAC TGG GGC CTG DYA*01012 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DYA*0102 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** 170 Exon 4 180 190 200 DYA*01011 GAA GAG CCT CGT CAA GCT GAC TGG G AG CCT GAG ATT CCA ACC CCT ACA TCA GAG CTG ACA GAG ACT GTG GTC TGT GCC CTG GGG CTG GCC ATG GGC CTC DYA*01012 *** *** *** *** *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DYA*0102 *** *** *** *** *** *** *** *** * ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** 210 220 DYA*01011 ATG GGC ATC GTG GTG GGC ACT GTC CTC ATC CTC CGA GTC CGG TGC TTG GGT GCT GCC TCC AGA CGT CGA AGG GCC ATG TGA DYA*01012 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** DYA*0102 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** ***

DIB Sequence

Exon 2 10 20 30 DIB*0101 AG AAT TTC GTG TAC CAG TTT AAA GGC ATG TGC TAC TTC ACC AAC GGG ACA GAG CAC GTG AGG CTT GTG GCC AGA CAG ATC TAC AAC AAG GAA GAG ATC CTG 40 50 60 DIB*0101 CAC TTT GAC AGT GAC CTG GGC GAG TTT GTG GCT GTT ACA GAG CTG GGC CGG GTG TGT GCG GAG ATC TGG AAC ACC CAG AAG GAC CTC CTG GCG GAG TTT CGG 70 80 90 Exon 3 100 DIB*0101 GCC TAC GTG GAC ACG CTG TGT AGA CAC AAC TAC AAA GAG ACG GCC GGC TTC ACT GTC CAG CGG AGA G TG GAG CCT ACA GTG ACT GTC TCT CCA GCC AGT 110 120 130 DIB*0101 ACA GAG GCC CTG AAC CAC CAT AAT CTG CTG GTC TGT TCA GTG ACA GAT TTC TAC CCT CGC CAA GTT AAA GTC AAA TGG TTC CGG AAT CAA CAG GAG CAG ACA 140 150 160 DIB*0101 ACA GCT GGA GTT GGG TTC ACA CCT CTT ACT CAG AAT GGG GAC TGG ACC TAC CAG ATT CAC GTG ATG CTA GAG ACA GTT CCA CAG CTT GGA GAC GTC TAC GTT 170 180 Exon 4 190 200 DIB*0101 CAC GTG GAC CAC CCC AGC CTC CAG AGC CCC ATC ACA GTA GAA TGG C GG GCA CAG TCT GAA TCA GCC CAG AGC AAG ATG CAG AGC GGA ATT GGA GGT TTT 210 220 DIB*0101 GTG CTG GGG CTG ATC TTC CTT GGT GTG GGC CTT TTT GTC CAC TTT TGG GAT AAG AGA G

DMA Sequence

alpha-1 domain Signal peptide 1 DMA*0101 ATG GAT CAT GAG CTG AGC CAG GAA GAT GTG CTG CTA CGG CTG CTC TCC TTT CTG TGG CTG CTG CCC CTG TCC TGG ACC GCC CCT GAA GCT CCT GCT CCA 10 20 30 40 DMA*0101 GGG TGG AGG GAT GAG CTA CAA AAC CAC ACG TTC CTG CAC ACA ATG TAC TGC CAG GAC TGG AGC CCC AAC GTG GCG CTC TCT GAG TCC TAC GAC GAG GAC CAG 50 60 70 DMA*0101 CTT TTC TCC TTC GAC TTT TCC CAG AGC ATC CGA GTG CCT CGC TTG CCT GAA TTT GCT GAC TGG GCT CAC CAG CAC GGA GAT ACT TCT GAC ATT ATG TTT GAC alpha-2 domain 80 90 100 DMA*0101 AAA GGT TTT TGC CGG GCC ATG ATC GAG GAA ATT GGC CCA GAA CTT GAA GGG CAA ATC CCA GTG TCT AGA GGG TTC CCC ATC GTT CAG GTG TTC ACA CTG 110 120 130 140 DMA*0101 AAG CCC CTG GAG TTT GGC AAG CCC AAC ACG CTG GTC TGT TTC ATC AGT AAT CTC TTT CCA CCC ACA CTG ACC GTG AAC TGG CAG CAT CAG TCG GCA CCT GTG 150 160 170 DMA*0101 GAA GGA GCC GGG CCC ACT TTT GTC TCC GCG GTT GAT GGA CTC ACC TTC CAG GCC TTT TCC TAC TTA AAC GTC ACA CCA GCA CCC TCT GAT CTT TTC TCT TGC 180 190 CP/TM/CY 200 DMA*0101 ATC GTG ACT CAT GAG ATC GAT GGC TAC ACA GCA ATC GCT TTT TGG GTG CCC CAG AAC GCG CTG CCC TCT GAT CTT CTG GAG AAT GTG CTG TGC GGC GTG 210 220 230 DMA*0101 GCC TTT GGC CTG GGT GTG CTG GGC ATC ATT GTT GGC TTG GTC CTC TTC TAC TGC CGA AAG CCG TGC TTA GGG GGC TGA

CP - connecting peptide;
TM - transmembrane region;
CY - cytoplasmic domain

DMB Sequence

beta-1 domain Signal peptide 1 10 DMB*0101 ATG ACT GTC CTC CTG TCG CTG CTG CTG GGC TTC AGC CTG GGC TGC ACC GCA GCA GGT GGT TTT GTG GCA CAC GTG GAA AGC ACC TGT GTG TTG GAC GAT 20 30 40 DMB*0101 GAT GGG GAT CCG AAA GAC TTC TCG TAT TGC ATC TCC TTC AAC AAG GAT TTG CTG ACC TGC TGG GAT CCC CTG CAG GCC AGT ATG ATT CCT CGT GAA TTT GGG 50 60 70 80 DMB*0101 GTG CTG AAC GGC TTG GCC CGG TAC CTC TCA CAG TTC CTC AAC AAT AAT AGT TAC CTG ATC CAG CGC TTG TCC AAT GGT CTG CAG AAC TGT GCC GCG CAC ACC 90 beta-2 domain 100 110 DMB*0101 CAG CCC TTC TGG AGC TCT CTG ACC CAC AGG ACA CGC CCA CCG ACC GTG CAG GTA GCC AAA ACC ACT CCT TTT AAC ACG AGG GAG TCT GTG ATG CTG GCC 120 130 140 150 DMB*0101 TGC TAT GTG TGG GGC TTC TAT CCA GCG GAC GTG GCC ATC ACG TGG AGG AGG AAC GGG CAG GAG GTC CTC CCA CAC GGC AGG GCC TGG AGG ATC ATC CAG CCC 160 170 180 DMB*0101 AAC GGA GAC TGG ACA TAC CAG ACC GTC TCC CAT CTG GCC ACA ACC CCC TCT TTT GGG GAT ACC TAC ACC TGT GTG GTC GAG CAC ATT GGG GCT CCT GAA CTC CP/TM/CY 190 200 210 DMB*0101 ATC CTT CAG GAC TGG ACT CCT GGG CTG TTG CCT GCG CAG ACG GTG AAG GTT TCT GTG GCT CTG GTA ACG CTG GTC CTG GGT CTC ATC ATC TTC GTT TTC 220 230 240 DMB*0101 GGT CTG CAC AGT TGG CGG AGA GCC ACC TCC TCC GGC TAC ATT TTC CTC CCG GGG TCC ACT TAT CCA GAA GGT CAG CAC AAT TGA

CP - connecting peptide;
TM - transmembrane region;
CY - cytoplasmic domain