Welcome
to the BoLA Nomenclature Committee
Web Site. This is intended to be the definitive source of
information on the bovine major histocompatibility complex - its
genes, proteins and polymorphism.
The
BoLA nomenclature committee is a standing committee of the International
Society for Animal Genetics. Its purpose is to collate data
on the Bovine Leucocyte Antigens (BoLA) and provide a forum for
the analysis and nomenclature of polymorphisms in the genes and
proteins of the bovine MHC.
How
the site is organised
The
information gathered here is based on the BoLA workshop reports,
which are published in Animal
Genetics and the European
Journal of Immunogenetics. The workshop report data are reproduced
with the permission of the publishers Blackwell
Science, and other text on the site is used with the permission
of CRC Press. The committee
acknowledges their co-operation in making this site possible.
Recognised
BoLA complex genes
|
Name
|
Molecular
characteristics
|
References
|
|
BoLA-class
I
|
Class
I -chain
|
|
|
BoLA-DRA
|
DR
alpha-chain, monomorphic
|
van
der Poel et al. (1990)
|
|
BoLA-DRB1
|
DRB
pseudogene
|
Muggli-Cockett
& Stone (1988)
|
|
BoLA-DRB2
|
DR
beta-chain, low level of transcription
|
Muggli-Cockett
& Stone (1989)
|
|
BoLA-DRB3
|
DR
beta-chain, expressed at high level
|
Groenen
et al. (1990); Burke et al. (1991)
|
|
BoLA-DQA*
|
DQ
alpha-chain, expressed
|
van
der Poel et al. (1990)
|
|
BoLA-DQB*
|
DQ
beta-chain, expressed
|
Groenen
et al. (1990)
|
|
BoLA-DOB
|
DO
beta-chain, not known to be expressed
|
Andersson
& Rask (1988)
|
|
BoLA-DOA
|
DNO
alpha-chain, not known to be expressed
|
Andersson
et al. (1988)
|
|
BoLA-DYA
|
DY
alpha-chain, selectively expressed
|
van
der Poel et al. (1990); Andersson et al. (1988)
|
|
BoLA-DYB
|
DY
beta-chain, not known to be expressed
|
Andersson
et al. (1988)
|
|
BoLA-DIB
|
DI
beta-chain, selectively expressed
|
Stone
& Muggli-Cockett (1990)
|
|
BoLA-DMA
|
DM
alpha-chain, expressed
|
Niimi
et al. (1995)
|
|
BoLA-DMB
|
DM
beta-chain, expressed
|
Niimi
et al. (1995)
|
|
TAP2
|
Peptide
transporter
|
Ambagala
et al (2002)
|
|
LMP2
|
Proteosome-related
sequence
|
Shalhevet
et al. (1996)
|
|
LMP7
|
Proteosome-related
sequence
|
Davies
et al. (1992)
|
